Chlorobutyric Acid
4-CBA, gamma-Chlorobutyric acid, 4-Chlorobutanoic acid.
- CAS
- 627-00-9
- EC
- 210-975-2
- Sectors
- Pharma & Healthcare, Plastics & Polymers
Chlorobutyric Acid (CAS 627-00-9) is a specialized carboxylic acid supplied as a clear, colorless to almost colorless liquid, built on a reactive four-carbon chain with a terminal halogen that makes it a versatile organic intermediate for cyclization reactions and the primary precursor to gamma-butyrolactone (GBL). It is the primary precursor for the production of gamma-butyrolactone (GBL) , a vital industrial solvent. Its high purity is critical for manufacturers in the pharmaceutical sector developing complex heterocyclic compounds. The compound is also utilized as a modifying agent in the production of performance polymers and plasticizers. Its chemical versatility allows for the creation of various esters used in heavy industrial research .
Typical Properties
| Molecular formula | C4H7ClO2 |
|---|---|
| Molecular weight | 122.55 g/mol |
| Form | clear liquid |
| Color | Colorless to Almost colorless |
| Melting point | 16 °C |
| Boiling point | 67-72 °C @ Press: 2.5 Torr |
| Density | 1.2373 g/cm³ @ Temp: 20 °C |
| Flash point | >230 °F |
| GHS signal word | Danger · Corrosive, Irritant / harmful |
| HS code | 29159000 |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Chlorobutyric Acid
Applications
- Pharma Intermediates: Used to synthesize medications targeting the central nervous system and other therapeutic areas.
- GBL Production: Acts as the direct chemical precursor for gamma-butyrolactone and pyrrolidone derivatives.
- Polymer Modification: Utilized in the synthesis of specialty plasticizers to improve resin flexibility.
Safety & Risks
Causes severe skin burns and eye damage. Harmful if swallowed. Handling requires acid-resistant PPE, including nitrile gloves, goggles, and aprons.
Packaging
200 kg plastic drums; 1000L IBC totes for large-scale industrial consumers.