Diphenhydramine Hydrochloride
Diphenhydramine HCl, DPH HCl, Benzhydramine hydrochloride.
- CAS
- 147-24-0
- EC
- 205-687-2
- Sectors
- Pharma & Healthcare, Personal Care & Cosmetics
Diphenhydramine Hydrochloride (CAS 147-24-0) is a first-generation H1-antagonist API supplied as a white crystalline powder that dissolves readily in water, and it is used as the active ingredient in allergy tablets and syrups, OTC sleep aids, and topical anti-itch creams. This white crystalline powder is highly soluble in water, facilitating rapid absorption in liquid and solid dosages. Its chemical stability and high purity grades are critical for meeting stringent pharmacopeia standards in healthcare manufacturing. In the cosmetics and personal care sector, it is utilized in topical formulations to provide anti-itch relief. Its dual role as a sedative agent and allergy treatment makes it a versatile staple in over-the-counter (OTC) medicine.
Typical Properties
| Molecular formula | C17H21NO.ClH |
|---|---|
| Molecular weight | 291.82 g/mol |
| Appearance | white crystalline powder |
| Form | Crystalline Powder or Adhering Crystals |
| Color | White |
| Melting point | 166-170 °C |
| Boiling point | 343.7 °C |
| Density | 1.20 g/cm³ (Solid) |
| Water solubility | 1000 g/L |
| Flash point | 9°C |
| pH | pH(100g/L, 25°C) 4.0～5.5 |
| GHS signal word | Danger · Irritant / harmful, Health hazard |
| HS code | 29221990 |
| Grades available | Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Diphenhydramine Hydrochloride
Applications
- Antihistamine Formulations: Primary active ingredient in tablets and syrups for treating allergic rhinitis and common cold symptoms.
- Topical Gels: Integrated into anti-pruritic creams to provide localized relief from insect bites and skin irritations.
- Sleep Aids: Leveraged for its sedative side effects in OTC night-time sleep aids and calming medications.
Safety & Risks
Harmful if swallowed and may cause drowsiness or dizziness. Professional handling requires protective eyewear, lab coats, and gloves to prevent accidental ingestion or skin contact.
Packaging
25 kg fiber drums with double PE liners; smaller custom packaging available for R&D laboratories.