Benfotiamine
Benzoylthiamine monophosphate, Benzoylthiamine O-monophosphate, benzoylthiaminemonophosphate, benzoylthiamineo-monophosphate
- CAS
- 22457-89-2
- EC
- 245-013-4
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Benfotiamine (CAS 22457-89-2), also known as benzoylthiamine monophosphate, is a lipid-soluble S-acyl derivative of thiamine (Vitamin B1) that appears as a white to off-white crystalline solid and is supplied in food grade and pharma grade for nutraceutical and food applications. It presents as a white to off-white crystalline solid, density 1.444 g/cm³, melting point 165 °C (decomp.), with greater membrane permeability than water-soluble thiamine salts.
As a Vitamin B1 derivative, benfotiamine supports authorised EU health claims (Reg. 432/2012) relating to normal energy-yielding metabolism, nervous system function, cardiac function, and psychological function. SoleChem supplies food grade and pharma grade material for use across nutraceutical, food, and pharmaceutical manufacturing sectors.
Typical Properties
| Molecular formula | C19H23N4O6PS |
|---|---|
| Molecular weight | 466.45 g/mol |
| Form | Solid |
| Color | White to Off-White |
| Melting point | 165 °C (decomp) |
| GHS signal word | Warning · Irritant / harmful |
| Grades available | Food Grade, Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Benfotiamine
Applications
- Pharmaceuticals: active ingredient meeting documented purity specifications for dosage forms
- Nutraceuticals & supplements: enhanced bioavailability over standard thiamine salts
- Food & nutrition: functional food and beverage Vitamin B1 fortification
- Animal feed: stable, fat-soluble B1 for premix and compound feed
- Cosmetics: Vitamin B1 derivative in specified topical formulations
Safety & Risks
GHS Warning: H315 (skin irritation), H319 (serious eye irritation), H335 (respiratory irritation). Use PPE including gloves and eye protection. Handle in ventilated area. Low acute systemic hazard. Store away from moisture and heat.
Packaging
Supplied in 25 kg fibre drums or cartons; 1 kg and 5 kg packs available for small lots. Store cool, dry, away from light.