Calcifediol (25-Hydroxyvitamin D3)
25-Hydroxycholecalciferol, 25-HYDROXYCHOLECALCIFEROL, 25-Hydroxyvitamin D, 25-Hydroxyvitamin D3
- CAS
- 19356-17-3
- EC
- 242-990-9
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Calcifediol (25-Hydroxyvitamin D3, CAS 19356-17-3) is the principal circulating metabolite of cholecalciferol, a white to off-white crystalline solid used in pharma-grade vitamin D formulations, functional foods and nutraceutical products, and holds authorized health claims covering normal calcium and phosphorus absorption, bone and teeth maintenance, and immune system function. Predicted density 1.01 g/cm³, melting point 74–76 °C, boiling point approximately 529 °C. Also identified as 25-hydroxycholecalciferol (CAS 19356-17-3; EC 242-990-9), it carries authorised EU health claims (Reg.
Typical Properties
| Molecular formula | C27H44O2 |
|---|---|
| Molecular weight | 400.64 g/mol |
| Form | White to off-white crystalline solid. |
| Color | White to off-white |
| Melting point | 74-76 °C |
| Flash point | 14 °C |
| GHS signal word | Danger · Acute toxicity, Health hazard |
| HS code | 29362900 |
| Grades available | Food Grade, Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Calcifediol (25-Hydroxyvitamin D3)
Applications
- Pharmaceuticals: active ingredient targeting vitamin D insufficiency in Rx and OTC.
- Nutraceuticals & Supplements: pharma-grade precursor in vitamin D supplement formulations.
- Animal Feed: bioavailable vitamin D source in veterinary and livestock nutrition.
- Food & Nutrition: functional food ingredient requiring calcifediol bioavailability data.
- Cosmetics: topical vitamin D-active ingredient for skin-related applications.
Safety & Risks
GHS classification: Danger. H301, H311, H330 (toxic if swallowed, in contact with skin, or inhaled); H372 (causes organ damage through prolonged exposure). Wear full PPE including respirator, gloves, and eye protection. Store sealed, away from light and moisture, at cool temperatures.
Packaging
Supplied in 25 kg drums or cartons; 1–5 kg small-lot options available. Store cool, dry, and light-protected.