Calcifediol (25-Hydroxyvitamin D3)
25-Hydroxycholecalciferol, 25-HYDROXYCHOLECALCIFEROL, 25-Hydroxyvitamin D, 25-Hydroxyvitamin D3
- CAS
- 19356-17-3
- EC
- 242-990-9
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Calcifediol (25-Hydroxyvitamin D3, CAS 19356-17-3) is the principal circulating metabolite of cholecalciferol, a white to off-white crystalline solid used in pharma-grade vitamin D formulations, functional foods and nutraceutical products, and holds authorized health claims covering normal calcium and phosphorus absorption, bone and teeth maintenance, and immune system function. Predicted density 1.01 g/cm³, melting point 74–76 °C, boiling point approximately 529 °C. Also identified as 25-hydroxycholecalciferol (CAS 19356-17-3; EC 242-990-9), it carries authorised EU health claims (Reg. 432/2012) covering normal calcium and phosphorus absorption, bone and teeth maintenance, muscle function, immune system function, and cell division.
Calcifediol (25-Hydroxyvitamin D3) is available from SoleChem as Food Grade and Pharma Grade material in 25 kg drums or cartons, with 1–5 kg small-lot options also offered.
SoleChem supplies these grades to nutraceutical and food and nutrition customers and holds ISO 9001:2015 and ISO 22000:2018 certification for the relevant operations. Shipments reach customers in more than 40 countries, and a certificate of analysis (COA) and safety data sheet (SDS) are provided with every delivery. To request a bulk quote, share the grade, packaging format and quantity you require.
Typical Properties
| Molecular formula | C27H44O2 |
|---|---|
| Molecular weight | 400.64 g/mol |
| Form | White to off-white crystalline solid. |
| Color | White to off-white |
| Melting point | 74-76 °C |
| Flash point | 14 °C |
| GHS signal word | Danger · Acute toxicity, Health hazard |
| HS code | 29362900 |
| Grades available | Food Grade, Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Applications by Industry
- Nutraceuticals & Supplements
Calcifediol (25-Hydroxyvitamin D3) is used by nutraceutical formulators as a pharma-grade precursor in vitamin D supplement formulations.
- Food & Nutrition
Calcifediol (25-Hydroxyvitamin D3) acts as a functional food ingredient for food and nutrition developers, with bioavailability data required for such uses.
Calcifediol (25-Hydroxyvitamin D3)
Applications
- Pharmaceuticals: active ingredient targeting vitamin D insufficiency in Rx and OTC.
- Nutraceuticals & Supplements: pharma-grade precursor in vitamin D supplement formulations.
- Animal Feed: bioavailable vitamin D source in veterinary and livestock nutrition.
- Food & Nutrition: functional food ingredient requiring calcifediol bioavailability data.
- Cosmetics: topical vitamin D-active ingredient for skin-related applications.
Safety & Risks
GHS classification: Danger. H301, H311, H330 (toxic if swallowed, in contact with skin, or inhaled); H372 (causes organ damage through prolonged exposure). Wear full PPE including respirator, gloves, and eye protection. Store sealed, away from light and moisture, at cool temperatures.
Packaging
Supplied in 25 kg drums or cartons; 1–5 kg small-lot options available. Store cool, dry, and light-protected.