Vitamin D3 Calcifediol Monohydrate (25-OH-D3)
25-HYDROXYCHOLECALCIFEROL, 25-hydroxycholecalciferol monohydrate, 25-HYDROXYVITAMIN D3, 25-hydroxyvitamin d3 monohydrate
- CAS
- 63283-36-3
- EC
- 621-370-5
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Vitamin D3 Calcifediol Monohydrate (25-OH-D3) is the primary circulating metabolite of cholecalciferol, supplied as white to light-yellow crystals with formula C₂₇H₄₆O₃ (monohydrate form) and molecular weight 400.64 g/mol. CAS 63283-36-3, EC 621-370-5.
As the 25-hydroxylated form of vitamin D3, calcifediol monohydrate offers higher bioavailability than parent cholecalciferol and is available in Food Grade and Pharma Grade. It is listed under Annex II of Directive 2002/46/EC (as amended by Reg. (EU) 2025/352) as an authorised vitamin D source for food supplements.
SoleChem, an ISO 9001:2015 certified chemical supplier based in Türkiye, delivers Vitamin D3 Calcifediol Monohydrate (25-OH-D3) (CAS 63283-36-3) to customers in more than 40 countries.
Vitamin D3 Calcifediol Monohydrate (25-OH-D3)
Applications
- Nutraceuticals & Supplements: authorised under Directive 2002/46/EC Annex II
- Pharmaceutical: pharma-grade, pre-hydroxylated, high-bioavailability vitamin D3
- Food & Nutrition: functional foods; excluded from Reg. 1925/2006 Annex II fortification
- Cosmetics: low-level topical use for vitamin D3 metabolite activity
- Animal Feed: feed premixes requiring enhanced bioavailability over cholecalciferol
Safety & Risks
GHS classification: Danger; H300 (fatal if swallowed), H310 (fatal in contact with skin), H330 (fatal if inhaled), H372 (specific target organ toxicity, repeated exposure). Handle with full PPE including gloves, eye protection, and respiratory protection. Store sealed, away from light and moisture.
Packaging
Supplied in 25 kg drums or cartons; 1–5 kg small-lot options available. Store in sealed containers in a cool, dry, dark location.