Vitamin D3 Calcifediol Monohydrate (25-OH-D3)
25-HYDROXYCHOLECALCIFEROL, 25-hydroxycholecalciferol monohydrate, 25-HYDROXYVITAMIN D3, 25-hydroxyvitamin d3 monohydrate
- CAS
- 63283-36-3
- EC
- 621-370-5
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Vitamin D3 Calcifediol Monohydrate (25-OH-D3) (CAS 63283-36-3) is the 25-hydroxylated metabolite of cholecalciferol, supplied as white to light-yellow crystals in monohydrate form, offering higher bioavailability than parent cholecalciferol and used in food supplements and functional foods. CAS 63283-36-3, EC 621-370-5.
As the 25-hydroxylated form of vitamin D3, calcifediol monohydrate offers higher bioavailability than parent cholecalciferol and is available in Food Grade and Pharma Grade. It is listed under Annex II of Directive 2002/46/EC (as amended by Reg. (EU) 2025/352) as an authorised vitamin D source for food supplements.
Vitamin D3 Calcifediol Monohydrate (25-OH-D3) is available from SoleChem as Food Grade and Pharma Grade material for nutraceutical and food customers. It ships in 25 kg drums or cartons, with 1–5 kg small-lot options, and should be stored in sealed containers in a cool, dry, dark location.
SoleChem holds ISO 9001:2015 and ISO 22000:2018 certification for food and nutraceutical products, and deliveries reach more than 40 countries. A certificate of analysis (COA) and safety data sheet (SDS) accompany every delivery. Request a bulk quote for your required grade and pack size.
Typical Properties
| Molecular formula | C27H44O2 |
|---|---|
| Molecular weight | 400.64 g/mol |
| Appearance | White or almost white crystals. |
| Form | neat |
| Color | White to Light yellow |
| Flash point | 14°C |
| GHS signal word | Danger · Acute toxicity, Health hazard |
| HS code | 29362900 |
| Grades available | Food Grade, Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Applications by Industry
- Nutraceuticals & Supplements
Vitamin D3 Calcifediol Monohydrate (25-OH-D3) serves supplement formulators as an authorised vitamin D source under Directive 2002/46/EC Annex II, and its pre-hydroxylated, high-bioavailability form supports pharma-grade applications.
- Food & Nutrition
Vitamin D3 Calcifediol Monohydrate (25-OH-D3) is used in functional foods, where it is excluded from Reg. 1925/2006 Annex II fortification, and its higher bioavailability compared with parent cholecalciferol supports Food Grade formulations.
Vitamin D3 Calcifediol Monohydrate (25-OH-D3)
Applications
- Nutraceuticals & Supplements: authorised under Directive 2002/46/EC Annex II
- Pharmaceutical: pharma-grade, pre-hydroxylated, high-bioavailability vitamin D3
- Food & Nutrition: functional foods; excluded from Reg. 1925/2006 Annex II fortification
- Cosmetics: low-level topical use for vitamin D3 metabolite activity
- Animal Feed: feed premixes requiring enhanced bioavailability over cholecalciferol
Safety & Risks
GHS classification: Danger; H300 (fatal if swallowed), H310 (fatal in contact with skin), H330 (fatal if inhaled), H372 (specific target organ toxicity, repeated exposure). Handle with full PPE including gloves, eye protection, and respiratory protection. Store sealed, away from light and moisture.
Packaging
Supplied in 25 kg drums or cartons; 1–5 kg small-lot options available. Store in sealed containers in a cool, dry, dark location.