HATU (CAS 148893-10-1) is a uronium-type peptide coupling reagent supplied as the hexafluorophosphate salt, a white to off-white crystalline powder used in pharmaceutical R&D for amide bond formation, peptide synthesis and other organic reactions requiring strong activating agents. It appears as a pale-yellow crystalline powder soluble in DMF and DCM.
Typical Properties
| Molecular formula | C10H15N6O.F6P |
|---|---|
| Molecular weight | 381.24 g/mol |
| Appearance | White crystalline to off-white powder |
| Form | powder to crystaline |
| Color | White to Almost white |
| Melting point | 183-188 °C (dec.) |
| Water solubility | Soluble in acetonitrile. Insoluble in water. |
| GHS signal word | Danger · Flammable, Irritant / harmful |
| HS code | 29339900 |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
HATU
Applications
Used in peptide synthesis, amide bond formation, and organic synthesis requiring strong activating agents. Preferred in pharmaceutical R&D for high-yield reactions.
Safety & Risks
Irritant to eyes and skin; handle in inert, moisture-free conditions. Use gloves and avoid inhalation of dust.
Packaging
Delivered in 1–5 kg amber glass bottles or aluminum drums. Store cool, dry, and inert, protected from light and humidity.