4-cyanopyridine
Isonicotinonitrile, 4-Pyridinecarbonitrile, p-Cyanopyridine, 4-CP.
- CAS
- 100-48-1
- EC
- 202-856-7
- Sectors
- Pharma & Healthcare, Agriculture
4-cyanopyridine (CAS 100-48-1) is a high-purity heterocyclic intermediate, supplied as white to off-white crystals or powder with a purity of ≥99%, that serves as the fundamental precursor for Isoniazid in tuberculosis treatment and as a building block for nicotinic acid derivatives and agrochemical compounds. It serves as a primary precursor for Isoniazid, a critical medication used in the global treatment of tuberculosis.
This crystalline solid is valued for its excellent reactivity in catalytic hydrogenation and hydrolysis reactions. It consistently meets a purity level of ≥99%, ensuring high yields and stability during sensitive industrial chemical synthesis cycles.
As a versatile specialty intermediate, it is also utilized in the production of nicotinic acid derivatives and specific agrochemical compounds. Its role as a molecular building block offers efficiency for large-scale organic synthesis operations.
Typical Properties
| Molecular formula | C6H4N2 |
|---|---|
| Molecular weight | 104.11 g/mol |
| Form | Crystals or Powder |
| Color | White to off-white |
| Melting point | 79 °C |
| Boiling point | 78 °C @ Press: 6 Torr |
| Water solubility | 3.2 g/100ml (16.4 °C) |
| Flash point | 88 °C |
| GHS signal word | Warning · Irritant / harmful |
| HS code | 29333999 |
| Grades available | Technical Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
4-cyanopyridine
Applications
- API Manufacturing: Acts as the fundamental precursor for the production of Isoniazid and other essential antitubercular drugs.
- Vitamin Production: Employed as a chemical intermediate in the industrial synthesis of Nicotinic Acid (Vitamin B3) and Nicotinamide.
- Agrochemical Synthesis: Used in the formulation of specialized pesticides and herbicides that require stable pyridine-based structures.
Safety & Risks
4-cyanopyridine is harmful if swallowed or in contact with skin and acts as a skin and eye irritant. Handling requires a fume hood, nitrile gloves, and ANSI-approved safety goggles to prevent exposure.
Packaging
• 25 kg Fiber Drums
• 50 kg Plastic Drums
• Custom bulk packaging available upon request for industrial scales.