Pyridine (CAS 110-86-1) is a high-purity heterocyclic amine supplied as a colorless liquid, a polar aprotic solvent and nucleophilic catalyst used as a base for acid neutralization and as a building block for active pharmaceutical ingredients and agrochemical intermediates. It is characterized by its high alkalinity and its role as a fundamental nucleophilic catalyst for industrial chemical reactions.
This reagent-grade liquid is essential for acid neutralization and serves as a critical building block for active pharmaceutical ingredients (APIs). Its unique chemical structure ensures excellent miscibility with water and a wide range of organic solvents for high-yield processing.
In industrial manufacturing, Pyridine is valued for its thermal stability and effectiveness in the production of vitamin precursors. It provides a reliable medium for acylation and alkylation, making it a staple in the synthesis of fine chemicals and specialty polymers.
Typical Properties
| Molecular formula | C5H5N |
|---|---|
| Molecular weight | 58.08 g/mol |
| Form | Liquid |
| Color | colorless |
| Odor | Nauseating odor detectable at 0.23 to 1.9 ppm (mean = 0.66 ppm) |
| Melting point | -41.6 °C |
| Boiling point | 115.2-115.3 °C |
| Density | 0.98272 g/cm³ @ Temp: 20 °C |
| Water solubility | Miscible |
| Flash point | 68 °F |
| pH | 8.81 (H2O, 20°C) |
| GHS signal word | Danger · Flammable, Corrosive, Acute toxicity, Irritant / harmful, Health hazard, Environmental hazard |
| HS code | 29333100 |
| Grades available | Technical Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Pyridine
Applications
- Pharmaceutical Synthesis: Functions as a critical base and reaction solvent in the manufacturing of antibiotics, sulfadiazine, and various medicinal agents.
- Agrochemical Production: Used as a primary intermediate for the synthesis of high-efficiency herbicides, insecticides, and specialized crop protection chemicals.
- Analytical Chemistry: Acts as a vital component in Karl Fischer titration reagents and as a buffer in various laboratory diagnostic procedures.
Safety & Risks
Pyridine is a highly flammable liquid and vapor that is harmful if swallowed, inhaled, or in contact with skin. Always use nitrile gloves, chemical splash goggles, and a certified fume hood to prevent exposure to its toxic vapors.
Packaging
- 1 Liter Glass Bottles
- 25 kg HDPE Drums
- 200 kg Steel Drums