Pyrrolidine
Tetrahydropyrrole, Azacyclopentane, Tetramethyleneimine, Azolidine.
- CAS
- 123-75-1
- EC
- 204-648-7
- Sectors
- Pharma & Healthcare, Rubber & Elastomers
Pyrrolidine (CAS 123-75-1) is a clear, colorless, high-purity (≥99%) cyclic secondary amine that is miscible with water and most organic solvents, and it serves as a building block in pharmaceutical synthesis for antibiotics and neuroleptics and as a vulcanization accelerator in rubber production. It possesses a characteristic ammoniacal odor and is fully miscible with water and most organic solvents.
In the pharmaceutical sector, it serves as a critical intermediate for the production of diverse medications, including antibiotics and neuroleptics. Its reactive nitrogen center allows for the efficient synthesis of complex heterocyclic structures and drug candidates.
This compound also finds significant use in the polymer industry as a process catalyst and vulcanization accelerator. Its ability to form stable salts and derivatives makes it indispensable for manufacturing specialized rubbers and resin modifiers.
Typical Properties
| Molecular formula | C4H9N |
|---|---|
| Molecular weight | 71.12 g/mol |
| Appearance | colourless to pale yellow liquid with a penetrating |
| Form | Liquid |
| Color | Colorless to Almost colorless |
| Odor | at 0.10 % in propylene glycol. ammoniacal animal egg amine |
| Melting point | -63 °C |
| Boiling point | 86.71 °C |
| Density | 0.8520 g/cm³ @ Temp: 22.5 °C |
| Water solubility | Miscible with alcohol, ether, chloroform and water. |
| Flash point | 37 °F |
| pH | 12.9 (100g/l, H2O, 20°C) |
| GHS signal word | Danger · Flammable, Corrosive, Acute toxicity, Irritant / harmful, Health hazard |
| HS code | 29339900 |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Pyrrolidine
Applications
- API Synthesis: Acts as a fundamental intermediate in the manufacturing of pharmaceuticals such as piracetam, procyclidine, and various antibiotics.
- Rubber Vulcanization: Utilized as an accelerator to speed up the cross-linking process in synthetic and natural rubber production.
- Chemical Catalyst: Employed as a basic catalyst in organic reactions, including the synthesis of enamines and various specialty fine chemicals.
Safety & Risks
Classified as a Highly Flammable Liquid and Corrosive. It causes severe skin burns and is harmful if swallowed or inhaled.Strict PPE requirements include nitrile gloves, chemical goggles, and a face shield. Always use explosion-proof equipment and store in a flame-proof cabinet.
Packaging
Commonly supplied in 170 kg Steel Drums, 20 kg Pails, or ISO Tanks for bulk industrial distribution.