4-Picoline
4-Methylpyridine, p-Picoline, gamma-Picoline, 4-MP
- CAS
- 108-89-4
- EC
- 203-626-4
- Sectors
- Pharma & Healthcare, Agriculture
4-Picoline (CAS 108-89-4) is a monomethylpyridine that appears as a clear light yellow liquid and acts as a chemical intermediate for nitrogenous compounds, including pharmaceutical active ingredients and agrochemicals, while also serving as an organic catalyst and solvent in fine chemical reactions. This flammable liquid features a technical grade purity, making it an essential building block for producing agrochemicals and pharmaceutical active ingredients (APIs).
Known for its strong nucleophilicity, it serves as a versatile organic catalyst and solvent in specialized reactions across the fine chemical manufacturing sector.
Typical Properties
| Molecular formula | C6H7N |
|---|---|
| Molecular weight | 93.13 g/mol |
| Form | Liquid |
| Color | Clear light yellow |
| Odor | Obnoxious, Sweetish |
| Melting point | 3.66 °C |
| Boiling point | 145 °C @ Press: 760 Torr |
| Density | 0.9548 g/cm³ @ Temp: 20 °C |
| Water solubility | soluble |
| Flash point | 134 °F |
| GHS signal word | Danger · Flammable, Acute toxicity, Irritant / harmful, Health hazard |
| HS code | 29333955 |
| Grades available | Technical Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
4-Picoline
Applications
- Pharmaceutical Synthesis: Used as the primary precursor for Isoniazid, an essential antibiotic utilized globally in the medical treatment of tuberculosis.
- Agrochemical Production: Serves as a key intermediate for the manufacture of Picloram, a potent herbicide used for broad-leaved weed and brush control.
- Polymer Manufacturing: Utilized in the production of vinylpyridine, which is a functional monomer used to enhance the bonding properties of synthetic fibers.
Safety & Risks
4-Picoline is highly flammable and classified as toxic if swallowed, inhaled, or in contact with skin. It causes severe skin burns and eye damage. Handling requires the use of Chemical-resistant gloves, Safety goggles, and a Certified vapor respirator within a well-ventilated facility.
Packaging
- 200 kg Steel Drums
- 1000 kg IBC Tanks
- ISO Tanks for bulk industrial supply