Thiophene
Thiofuran, Tetrole, Thiacylopentadiene.
- CAS
- 110-02-1
- EC
- 203-729-4
- Sectors
- Pharma & Healthcare, Electronics & Solar PV, Agriculture
Thiophene (CAS 110-02-1) is a five-membered heterocyclic compound supplied as a colorless to pale yellow liquid with a distinct odor, and it serves as a fundamental building block in organic synthesis for pharmaceutical, agrochemical and electronic material applications. It is a high-purity liquid characterized by its distinct odor and reactivity in aromatic substitution.
This intermediate is essential for the production of Specialty Chemicals used in the electronics and polymer industries. Its derivatives are critical in manufacturing conducting polymers and high-efficiency organic light-emitting diodes (OLEDs).
In the life sciences sector, it serves as a core scaffold for API synthesis. Its unique electronic properties allow for the modification of pharmacological profiles in various therapeutic drug classes.
Typical Properties
| Molecular formula | C4H4S |
|---|---|
| Molecular weight | 84.14 g/mol |
| Appearance | colourless to pale yellow liquid |
| Form | powder |
| Color | Clear |
| Odor | at 0.10 % in propylene glycol. alliaceous garlic |
| Melting point | -39.4 °C |
| Boiling point | 84.0 °C @ Press: 760 Torr |
| Density | 1.06494 g/cm³ @ Temp: 20 °C |
| Water solubility | INSOLUBLE |
| Flash point | -9 °C |
| GHS signal word | Danger · Flammable, Corrosive, Acute toxicity, Irritant / harmful, Health hazard |
| HS code | 29349990 |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Thiophene
Applications
- Pharmaceutical Synthesis: Acts as a precursor for antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), and antifungal agents.
- Agrochemicals: Used in the manufacture of high-efficacy herbicides and fungicides for crop protection.
- Material Science: Serves as a monomer for polythiophene, a conductive polymer used in anti-static coatings and solar cells.
Safety & Risks
Classified as Highly Flammable Liquid and Harmful if swallowed. It is a Category 4 Acute Toxicant. Keep away from heat/sparks; use Explosion-proof Equipment and Protective Gloves/Goggles.
Packaging
200 kg Steel Drums, 1000 kg IBC Tanks, or specialized ISO containers for hazardous liquids.