2-Bromothiophene
2-Thienyl bromide, Monobromothiophene.
- CAS
- 1003-09-4
- EC
- 213-699-4
- Sectors
- Pharma & Healthcare, Electronics & Solar PV
2-Bromothiophene (CAS 1003-09-4) is a halogenated thiophene intermediate supplied as a clear, colorless to slightly brownish liquid that carries a reactive bromine site, making it a starting material for functionalized thiophene derivatives used in cross-coupling reactions, organic electronics and pharmaceutical synthesis. This compound is critical for the synthesis of conjugated polymers and small molecules in the organic electronics industry. Its reactive bromine site allows for precise molecular engineering in Suzuki and Stille coupling processes. In medical chemistry, it is used to introduce the thienyl group into active pharmaceutical ingredients (APIs) . It offers the high regioselectivity required for complex multi-step organic synthesis.
Typical Properties
| Molecular formula | C4H3BrS |
|---|---|
| Molecular weight | 163.04 g/mol |
| Appearance | colorless to light yellow liqui |
| Form | Liquid |
| Color | Clear colorless to slightly brownish |
| Melting point | <25 °C |
| Boiling point | 53-56 °C @ Press: 18 Torr |
| Density | 1.6284 g/cm³ @ Temp: 20 °C |
| Water solubility | IMMISCIBLE |
| Flash point | 140 °F |
| GHS signal word | Danger · Flammable, Corrosive, Acute toxicity, Irritant / harmful |
| HS code | 29349990 |
| Grades available | Electronic Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
2-Bromothiophene
Applications
- Organic Electronics: A key building block for thiophene-based semiconductors and organic photovoltaic (OPV) materials.
- Drug Discovery: Utilized in the synthesis of cardiovascular medications and central nervous system (CNS) active agents.
- Chemical Research: A standard reagent for exploring aromatic substitution and heterocyclic chemistry in laboratory settings.
Safety & Risks
Classified as Flammable Liquid and Toxic. Causes Serious Eye Irritation and is Harmful if inhaled. Handle under a Fume Hood using Viton Gloves and Safety Goggles.
Packaging
1 kg Glass Bottles, 25 kg Fluorinated Drums, or 200 kg Steel Drums.