2-Acetylthiophene
2-Thienyl methyl ketone, Methyl 2-thienyl ketone, 1-(2-thienyl)ethanone.
- CAS
- 88-15-3
- EC
- 201-804-6
- Sectors
- Pharma & Healthcare, Agriculture, Food & Nutrition
2-Acetylthiophene (CAS 88-15-3) is an aromatic ketone, also known as 2-thienyl methyl ketone, supplied as a clear colorless to slightly yellow liquid in Technical Grade, and it serves as a reactive acetyl-group building block for thienyl-based pharmaceuticals, specialty herbicides and roasted or nutty flavor and fragrance chemicals. It is a Technical Grade intermediate prized for its purity and predictable reactivity in condensation reactions.
This compound is widely used in the production of thienyl-based pharmaceuticals. It provides a reactive acetyl group that is essential for forming complex heterocyclic rings in drug development.
In the flavor and fragrance industry, it is utilized as a Specialty Chemical to provide specific roasted or nutty notes. Its high chemical stability makes it a reliable precursor for both fine chemicals and agrochemicals.
Typical Properties
| Molecular formula | C6H6OS |
|---|---|
| Molecular weight | 126.18 g/mol |
| Appearance | clear colorless to slightly yellow liquid |
| Form | Liquid |
| Color | Clear pale yellow to light brown |
| Odor | at 100.00 %. sulfurous nutty hazelnut walnut |
| Melting point | 10.5 °C |
| Boiling point | 214.0 °C |
| Density | 1.16711 g/cm³ (liquid) @ Temp: 65 °C; Press: 4.88 x 10⁵ Torr |
| Water solubility | Insoluble in water. |
| Flash point | 196 °F |
| GHS signal word | Danger · Acute toxicity, Irritant / harmful |
| HS code | 29349990 |
| Grades available | Technical Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
2-Acetylthiophene
Applications
- API Manufacturing: Used in the synthesis of Duloxetine and various other medications for neurological disorders.
- Crop Protection: Serves as a precursor for specialty herbicides that require specific heterocyclic structural motifs.
- Fragrance Chemistry: Employed as an intermediate to create unique aroma chemicals for industrial applications.
Safety & Risks
Classified as Acute Toxic (Category 3) and Combustible Liquid. It is Harmful to aquatic life. Wear Chemical-resistant Clothing, Respirators, and Gloves during transfer.
Packaging
25 kg Plastic Pails, 200 kg Steel Drums, or 1000 kg IBC Tanks.