Polysorbate 80
Tween 80
- CAS
- 9005-65-6
- EC
- 500-019-9
- Food Code
- E433
- Sectors
- Food & Nutrition, Pharma & Healthcare, Personal Care & Cosmetics
Polysorbate 80 (CAS 9005-65-6) is a surfactant derived from sorbitan monooleate ethoxylated with 20 moles of ethylene oxide, an amber-colored viscous liquid used to solubilize vitamins in oral supplements and to form micelles in intravenous pharmaceuticals. It provides superior solubilizing capabilities for hydrophobic compounds, maintaining stability in electrolyte-rich solutions and over a broad pH range from 3 to 11.
Typical Properties
| Molecular weight | 428.6 g/mol |
|---|---|
| Appearance | Yellow to amber liquid |
| Form | viscous liquid |
| Color | Amber |
| Odor | mild alcoholic |
| Melting point | 115.6 °C |
| Boiling point | >100 °C |
| Density | 1.06-1.10 g/cm³ |
| Water solubility | 5-10 g/100 mL at 23 °C |
| Flash point | >230 °F |
| pH | 5-7 (50g/l, H2O, 20°C) |
| HS code | 34021300 |
| Grades available | Food Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Polysorbate 80
Applications
Critical for solubilizing vitamins in oral supplements; in intravenous pharmaceuticals for micelle formation; in hair care products for detangling; in vaccine adjuvants for enhanced delivery; and in agricultural sprays as wetting agents improving pesticide efficacy on foliage.
Safety & Risks
FDA-approved with potential for allergic responses in individuals sensitive to oleic acid derivatives; high doses linked to minor digestive issues. Monitor for ethylene oxide residues per regulatory limits; utilize enclosed systems for handling to reduce vapor exposure and ensure compliance with occupational exposure thresholds.
Packaging
Contained in 200 liter high-density polyethylene totes with tamper-proof seals. Store in ventilated chemical bays, segregated from incompatible substances like peroxides to prevent unintended reactions.