Quinine Sulfate
Quinine Sulphate, Quinine hemisulfate salt, (8α,9R)-6'-Methoxycinchonan-9-ol sulfate.
- CAS
- 804-63-7
- EC
- 212-359-1
- Sectors
- Pharma & Healthcare, Food & Nutrition
Quinine Sulfate (CAS 804-63-7) is a highly purified cinchona alkaloid salt supplied as a white to off-white crystalline powder, recognized as a Pharmaceutical Grade active ingredient for antimalarial medicines and as the defining bitterant in tonic waters and soft drinks. This white crystalline powder meets rigorous industrial standards for consistency, offering high purity levels for critical applications.
As a Pharmaceutical Grade active ingredient, it serves as a vital component in treatments for malaria and nocturnal muscle cramps. It is also the fundamental bitterant used extensively within the global Food & Nutrition sector for beverage production.
The compound offers exceptional solubility in aqueous environments, making it an ideal API for both liquid and tablet formulations. Its chemical profile ensures compliance with international safety regulations for Technical Grade and food-safe chemical additives.
Typical Properties
| Molecular formula | C20H24N2O2.1/2H2O4S |
|---|---|
| Molecular weight | 746.91 g/mol |
| Form | Solid |
| Color | White to off-white |
| Odor | wh. fine needle-like cryst., odorless, very bitter taste |
| Melting point | 235.2 °C |
| GHS signal word | Warning · Irritant / harmful |
| HS code | 29339900 |
| Grades available | Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Quinine Sulfate
Applications
- Antimalarial API: Used as the primary active pharmaceutical ingredient in medications targeting Plasmodium falciparum and other parasitic infections.
- Beverage Bittering: Employed as the essential flavoring agent to provide the signature bitter taste in high-end tonic waters and soft drinks.
- Analytical Fluorescent Standard: Utilized in laboratory environments as a reference material for calibrating spectrofluorometers due to its stable emission in acidic solutions.
Safety & Risks
This substance is classified as Harmful if swallowed and a Respiratory/Skin Sensitizer. Operators must wear Nitrile gloves, Safety goggles, and a Certified P2 dust respirator to prevent accidental exposure or inhalation.
Packaging
Available in 1 kg / 5 kg Aluminum Foil Bags for high-value research and specialty batches, or 25 kg Fiber Drums for large-scale industrial manufacturing.