Vitamin E Tocofersolan (TPGS)
Tocofersolan, TPGS, D-α-Tocopherol polyethylene glycol 1000 succinate, Vitamin E Polyethylene Glycol Succinate
- CAS
- 9002-96-4
- EC
- 618-345-6
- Sectors
- Pharma & Healthcare, Nutraceuticals & Supplements, Personal Care & Cosmetics
Vitamin E Tocofersolan (TPGS) (CAS 9002-96-4) is a water-soluble vitamin E ester made by esterifying d-α-tocopherol with polyethylene glycol 1000 succinate, supplied as a white to pale yellow waxy solid that acts as a solubilizer, emulsifier and bioavailability enhancer in pharmaceutical, nutraceutical and personal care systems. Formula (C₂H₄O)ₙC₃₃H₅₄O₅; MW 662.94 g/mol. Its amphiphilic structure enables incorporation of fat-soluble actives into aqueous systems, making it a standard excipient in pharmaceutical, nutraceutical, and personal care manufacturing. Available in Food Grade and Pharma Grade (USP/Ph.Eur.) specifications.
Typical Properties
| Molecular formula | (C2H4O)nC33H54O5 |
|---|---|
| Molecular weight | 662.942 g/mol |
| Form | Solid |
| Color | White to Pale Yellow Waxy |
| Melting point | 40 °C |
| Water solubility | H2O: 1g/10 mL, clear to faintly turbid, colorless to faintly yellow |
| Grades available | Food Grade, Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Vitamin E Tocofersolan (TPGS)
Applications
- Sector: Pharma — excipient improving oral bioavailability of poorly water-soluble APIs.
- Sector: Nutraceuticals — enables water-dispersible vitamin E in pediatric supplements.
- Sector: Food fortification — carries fat-soluble vitamins in clear fortified beverages.
- Sector: Cosmetics — emulsifier stabilising oil-in-water topical emulsions.
- Sector: Biochemical research — solubilises lipophilic compounds in vitro.
Safety & Risks
Not classified as hazardous under GHS. Low acute toxicity; handle with standard industrial hygiene. Avoid eye contact; use appropriate PPE. Store away from heat sources above 40 °C; keep containers sealed in a cool, dry location.
Packaging
Supplied in 25 kg drums or cartons; 1–5 kg containers available for small-lot orders. Store cool and dry, below 25 °C.