Climbazole
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one.
- CAS
- 38083-17-9
- EC
- 253-775-4
- Sectors
- Personal Care & Cosmetics
Climbazole (CAS 38083-17-9) is a Cosmetic Grade antifungal agent supplied as a white to almost white crystalline powder of minimum 99% purity that acts against Malassezia furfur, the fungus linked to dandruff, and is used in anti-dandruff shampoos, antifungal skin creams and leave-on conditioners. It demonstrates exceptional biocidal activity against Malassezia furfur, the primary fungus responsible for dandruff formation.
This crystalline powder is known for its high purity (min 99%) and excellent stability across a wide pH range. It is easily incorporated into shampoos and lotions, providing therapeutic efficacy without stripping the hair’s natural moisture.
Beyond its primary function, Climbazole acts as a preservative booster to enhance the microbiological stability of leave-on products. It is the preferred choice for high-end formulations requiring targeted antimicrobial performance.
Typical Properties
| Molecular formula | C15H17ClN2O2 |
|---|---|
| Molecular weight | 292.76 g/mol |
| Form | neat |
| Color | White to Almost white |
| Melting point | 98.000 °C |
| Water solubility | 58mg/L at 25°C |
| GHS signal word | Warning · Irritant / harmful, Environmental hazard |
| HS code | 29332900 |
| Grades available | Cosmetic Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Climbazole
Applications
- Anti-Dandruff Shampoos: Primary active ingredient used to treat scalp conditions and reduce flaking and itching.
- Antifungal Skin Creams: Incorporated into topical treatments to prevent fungal growth and soothe irritated skin.
- Leave-on Conditioners: Used in low concentrations to maintain scalp health and provide long-lasting antimicrobial protection.
Safety & Risks
Classified as Acute Toxic (Oral). Avoid inhalation of dust; use Dust Masks (N95) and Nitrile Gloves during material transfer and weighing.
Packaging
Supplied in 25 kg Fiber Drums with inner PE lining for moisture protection.