Tilmicosin phosphate
Tilmicosin phosphate salt, 20-Deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin phosphate, USP Tilmicosin Phosphate
- CAS
- 137330-13-3
- EC
- 641-061-9
- Sectors
- Pharma & Healthcare, Animal Nutrition
Tilmicosin phosphate (CAS 137330-13-3) is a semi-synthetic macrolide antibiotic salt derived from tylosin, supplied as a white to off-white solid Pharma Grade powder and used as the active ingredient in veterinary injectables, feed premixes and water solubles for respiratory disease in cattle, sheep and swine. Produced as a premium API grade powder, it ensures exceptional purity and consistency for the formulation of sterile injectables and medicated feeds.
Engineered to combat respiratory pathogens, this compound exhibits potent bacteriostatic activity against Gram-positive bacteria and Mycoplasma species in livestock. Its mechanism disrupts bacterial protein synthesis, making it a critical component in the treatment of Bovine Respiratory Disease (BRD) and swine pneumonia.
Unlike its free base form, the phosphate salt offers superior water solubility, significantly enhancing bioavailability and formulation stability in liquid carriers. This physicochemical advantage allows manufacturers to create efficient veterinary solutions that deliver rapid therapeutic onset for herd health management.
Typical Properties
| Molecular formula | C46H83N2O17P |
|---|---|
| Molecular weight | 967.13 g/mol |
| Form | Solid |
| Color | White to Off-White |
| Melting point | >160°C (dec.) |
| GHS signal word | Warning · Irritant / harmful, Health hazard, Environmental hazard |
| Grades available | Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Tilmicosin phosphate
Applications
- Veterinary Therapeutics:Primary active ingredient in injectable solutions for treating respiratory diseases in cattle and sheep caused by Mannheimia haemolytica.
- Swine Health Management: Used in feed premixes and water solubles to control swine respiratory disease associated with Actinobacillus pleuropneumoniae.
- Medicated Feed Additives: Incorporated into animal nutrition formulations as a prophylactic measure to maintain herd health and prevent bacterial outbreaks in intensive farming.
Safety & Risks
Handling requires extreme caution as the substance is cardiotoxic to humans if accidentally injected; strict safety protocols are mandatory. It is classified as an irritant to eyes and respiratory systems and may cause skin sensitization. Personnel must utilize full Personal Protective Equipment (PPE), including chemical-resistant gloves, safety goggles, and respiratory protection to prevent exposure during processing.
Packaging
• 10 kg / 25 kg Fiber Drums (with double PE liners)
• 5 kg Aluminum Foil Bags