Vitamin B5 Pantethine
Bis(pantothenamidoethyl) disulfide, D-Bis-pantothenyl-β-aminoethyl disulfide, D-Pantethine, D-PANTETHINE
- CAS
- 16816-67-4
- EC
- 240-842-8
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Vitamin B5 Pantethine (CAS 16816-67-4) is the disulfide dimer of pantetheine, a coenzyme A precursor in the vitamin B5 family, supplied as a colorless to pale yellow viscous liquid or syrup for nutraceutical supplements under Annex II, Directive 2002/46/EC, and functional food energy metabolism claims under Regulation 432/2012. CAS 16816-67-4, EC 240-842-8. Also known as bis(pantothenamidoethyl) disulfide or D-pantethine.
The substance presents as a colorless to pale yellow, clear, viscous liquid or syrup at ambient conditions, with crystals obtainable from methanol/acetone; density approximately 1.19 g/cm³. It functions as a biologically active form of pantothenic acid, playing a central role in acyl-carrier and coenzyme A-dependent metabolic pathways.
Typical Properties
| Molecular formula | C22H42N4O8S2 |
|---|---|
| Molecular weight | 554.73 g/mol |
| Appearance | Colorless to pale yellow, clear, viscous liquid |
| Form | syrup |
| Color | Crystals from MeOH/Me2CO |
| GHS signal word | Warning · Environmental hazard |
| Grades available | Food Grade, Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Vitamin B5 Pantethine
Applications
- Nutraceuticals & Supplements: listed in Annex II, Directive 2002/46/EC.
- Functional Food & Nutrition: authorised under Regulation 432/2012 for energy metabolism claims.
- Pharmaceuticals: active ingredient in metabolically active pantothenic acid derivative preparations.
- Cosmetics: skin-conditioning agent exploiting hygroscopic, viscous liquid properties.
- Biochemical Research: substrate in coenzyme A biosynthesis and acyl-transfer enzyme assays.
Safety & Risks
GHS Warning; H400 (very toxic to aquatic life). Low acute hazard to humans. Avoid release to aquatic environments. Use standard PPE — gloves, eye protection. Store sealed, away from moisture and heat.
Packaging
Supplied in 25 kg drums or cartons; 1–5 kg small-lot options available. Store cool, dry, and tightly sealed.