Calcium Folinate (leucovorin)
5-FORMLYL-5,6,7,8-TETRAHYDROFOLIC ACID, CALCIUM SALT, Calcium 5-formyltetrahydrofolate, calcium folinate, Calcium Folinate
- CAS
- 1492-18-8
- EC
- 216-082-8
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Calcium Folinate (leucovorin) is the calcium salt of 5-formyltetrahydrofolic acid, a reduced, coenzyme-active form of Vitamin B9. It carries the formula C20H23N7O7·Ca with a molecular weight of 511.5 g/mol, and presents as a pale to light yellow powder with a melting point above 300°C.
As a metabolically active folate derivative, calcium folinate participates directly in one-carbon transfer reactions, supporting amino acid synthesis, nucleotide biosynthesis, and blood cell formation without requiring prior enzymatic reduction.
SoleChem, an ISO 9001:2015 certified chemical supplier based in Türkiye, delivers Calcium Folinate (leucovorin) (CAS 1492-18-8) to customers in more than 40 countries.
Calcium Folinate (leucovorin)
Applications
- Nutraceuticals & Supplements: EU-authorised health claims; blood formation, immune function, homocysteine.
- Pharmaceuticals: pharma-grade active in injectable and oral leucovorin.
- Food & Nutrition: food-grade powder for functional food and beverage fortification.
- Animal Feed: folate source for livestock and companion animal feed.
- Biochemical Research: reference-grade for enzymatic assays and tetrahydrofolate studies.
Safety & Risks
GHS classification: Danger. H315 skin irritation, H317 skin sensitisation, H319 serious eye irritation, H334 respiratory sensitisation, H335 respiratory irritation. Wear gloves, eye protection, and respiratory PPE. Store sealed, away from moisture and heat.
Packaging
Available in 25 kg drums or cartons; 1–5 kg small-lot options. Store in a cool, dry, well-ventilated location, protected from moisture.