Calcium Folinate (leucovorin)
5-FORMLYL-5,6,7,8-TETRAHYDROFOLIC ACID, CALCIUM SALT, Calcium 5-formyltetrahydrofolate, calcium folinate, Calcium Folinate
- CAS
- 1492-18-8
- EC
- 216-082-8
- Sectors
- Nutraceuticals & Supplements, Food & Nutrition
Calcium Folinate (leucovorin) (CAS 1492-18-8) is the calcium salt of 5-formyltetrahydrofolic acid, a reduced, coenzyme-active form of vitamin B9, supplied as a pale yellow to light yellow powder that supports amino acid synthesis, nucleotide biosynthesis and blood cell formation. It carries the formula C20H23N7O7·Ca with a molecular weight of 511.5 g/mol, and presents as a pale to light yellow powder with a melting point above 300°C.
As a metabolically active folate derivative, calcium folinate participates directly in one-carbon transfer reactions, supporting amino acid synthesis, nucleotide biosynthesis, and blood cell formation without requiring prior enzymatic reduction.
Calcium Folinate (leucovorin) is available from SoleChem in Food Grade and Pharma Grade, with deliveries to more than 40 countries. Both grades serve customers in the nutraceuticals and supplements and food and nutrition sectors. Packaging is offered in 25 kg drums or cartons, with 1–5 kg small-lot options also available for initial orders.
Shipments are supported by ISO 9001:2015 and ISO 22000:2018 certifications, and every delivery includes a certificate of analysis (COA) and a safety data sheet (SDS). Request a quote with your grade, quantity and delivery requirements.
Typical Properties
| Molecular formula | C20H23N7O7.Ca |
|---|---|
| Molecular weight | 511.5 g/mol |
| Form | powder |
| Color | Pale Yellow to Light Yellow |
| Melting point | >300°C |
| GHS signal word | Danger · Irritant / harmful, Health hazard |
| HS code | 29362900 |
| Grades available | Food Grade, Pharma Grade |
Typical literature values for identification; lot-specific results are stated on the certificate of analysis (COA) and the safety data sheet (SDS) that accompany every delivery.
Applications by Industry
- Nutraceuticals & Supplements
Calcium Folinate supports nutraceutical formulators in products addressing blood formation, immune function and homocysteine, where it serves as a coenzyme-active folate source covered by EU-authorised health claims.
- Food & Nutrition
Calcium Folinate serves food and beverage producers as a food-grade powder for the fortification of functional foods and drinks, offering an active form of vitamin B9 for formulation.
Calcium Folinate (leucovorin)
Applications
- Nutraceuticals & Supplements: EU-authorised health claims; blood formation, immune function, homocysteine.
- Pharmaceuticals: pharma-grade active in injectable and oral leucovorin.
- Food & Nutrition: food-grade powder for functional food and beverage fortification.
- Animal Feed: folate source for livestock and companion animal feed.
- Biochemical Research: reference-grade for enzymatic assays and tetrahydrofolate studies.
Safety & Risks
GHS classification: Danger. H315 skin irritation, H317 skin sensitisation, H319 serious eye irritation, H334 respiratory sensitisation, H335 respiratory irritation. Wear gloves, eye protection, and respiratory PPE. Store sealed, away from moisture and heat.
Packaging
Available in 25 kg drums or cartons; 1–5 kg small-lot options. Store in a cool, dry, well-ventilated location, protected from moisture.